The short was co-directed by Walt Disney and Ub Iwerks. Iwerks was also the sole animator for this short and spent just two weeks working on it in a back room, at a rate of over 700 drawings a day. It is also speculated Hugh Harman and Rudolf Ising might have done work for the short as well. The sound version contained a soundtrack by Carl W. Stalling, who recorded it on October 26, 1928, when he was hired, and a month before Steamboat Willie was released.
- In 1930, the story of Plane Crazy was adapted and used for the first story in the Mickey Mouse comic strip. This adaptation, entitled "Lost on a Desert Island," was written by Walt Disney with art by Ub Iwerks and Win Smith.
- In the Mickey Mouse short The Nifty Nineties (1941), Mickey and Minnie's car runs out of control and runs into a cow. The scene was taken almost directly from Plane Crazy.
- The cartoon Mickey's Airplane Kit (1999) from the series Mickey Mouse Works and House of Mouse featured a similar premise in which Mickey built his own airplane to impress Minnie.
- In the feature film Walt Before Mickey, Plane Crazy was featured.
- Plane Crazy plays in a continuous loop in the Main Street Cinema at Disneyland, albeit silently, next to Steamboat Willie.
- The airplane, horseshoe, and "How to Fly" book are on display as props from Plane Crazy in the queue of the Mickey & Minnie's Runaway Railway attraction at Disneyland.